Soyuz MS-29 launched on July 14, 2026, carrying three crew members to the International Space Station as part of Expedition 74/75. The mission delivered NASA astronaut Anil Menon and Roscosmos cosmonauts Pyotr Dubrov and Anna Kikina to the orbiting laboratory for an eight-month mission. The crewed spacecraft served as a routine crew rotation flight, bringing fresh personnel to maintain station operations and conduct scientific research in microgravity.

The Soyuz 2.1a vehicle lifted off from Site 31/6 at the Baikonur Cosmodrome in Kazakhstan at 2:47 PM UTC, operated by the Russian Federal Space Agency. The launch proceeded nominally from the historic launch facility, which has served as the primary departure point for human spaceflight to the ISS since the Space Shuttle program's retirement.

The mission achieved a successful outcome, with the Soyuz spacecraft docking to the nadir port of the Prichal module on the International Space Station. The arrival expanded the station's crew complement and ensured continuity of operations aboard humanity's permanent orbital outpost. This mission reflected the continued international cooperation between NASA and Roscosmos in human spaceflight.